The pathogenesis of multiple sclerosis (MS) involves a complex and dynamic interplay between the immune system and central nervous system (CNS) resident cells, including neurons and glial cells.1 These mechanisms contribute to the acute inflammation and diffuse neurodegeneration that characterize MS.1,2
View references on Mechanism of Disease.
Neuroglia are a network of cells in the brain and spinal cord that support the central nervous system by maintaining homeostasis, producing myelin, and protecting neurons from outside attack.1,3,4
Glial cells include astrocytes, microglia, and oligodendrocytes.1
Glial cells are activated when immune cells, including T cells, cross the blood-brain barrier and set in motion a chain of cellular reactions.5-8
View references on the Role of Glial Cells.
A quick overview of the biological mechanisms in multiple sclerosis (MS).
1. Lymphocyte Migration in MS
2. S1P and the Role of S1P Receptor-1 in Lymphocyte Migration
3. Diverse Biological Functions of S1P Receptors
4. Role of S1P Receptors in the Cardiovascular System
View references on Migration and Activation.